Low sugar intake increases hunger
for sweet foods and food supplements, regular exercise increases appetite and
increases need of glucose of muscles tissues, and following strict guidelines
increases victim’s indulgence to more carbohydrates, proteins and fats intake.
There should be alternate
replacement of water melon and salad diet in more handsome amount with
programmed macros intake.
Intaking sugar resistant medicine in
a regular basis couples with change in exercise, nutrition and life style
modules and gives better results.
Most importantly, intaking
cholesterol resistant medicine is must as more cholesterol will be released
from liver for homeostasis which will speed up glucose indulgence to blood
stream. Also, more load is been imposed to muscles tissues to intake more
glucose through medication, exercise and precautionary measures. The organs and
organs systems also realize more load in their functioning.
So imbalance in homeostasis is one
and only cause for high blood glucose levels not going down even we exercise
regularly, take balanced diet, intake medicines regularly, and follow strict
life style. So maintenance of overall homeostasis with regular exercises,
programmed diet, programmed life style activities and following
self-precautionary measures is one and only way to control diabetes.
Other homeostasis like fats and
lipids profile and metabolism, insulin resistance metabolism, protein synthesis
metabolism, carbohydrates metabolism, sleeping mechanism, etc. should be
maintained for overall homeostasis.
Regular medications only retard
normal flow of glucose from food we intake to blood stream. They can control
and stop blood glucose level to a point not to go abruptly to blood stream but
cannot make blood glucose levels go down with time.
When we stop exercising, our food
macros and intake levels, feeding habits and patterns will be scrutinized. This
will lead medication inefficiency and our blood glucose levels will go up.
More carbohydrates, proteins, oils
and fats intake will give extra load to liver causing more cholesterol release
, more load to muscles tissues and more load to organs and organs systems which
spoils overall homeostasis and even we take regular medications blood glucose
level does not goes down.
Exercise, nutrition changes, life
style management, self-precautionary measures, most importantly, increasing
efficiency and health management of liver to avoid extra release of
cholesterol, and conscience of imbalances brought about my up and downs made in
different parameters of change needed intentionally or unintentionally and
simultaneous adjustments is a must.
Medicine controls blood glucose
level when you exercise, diet, change in life style and follow
self-precautionary measures to main overall homeostasis in cognition.
Imbalance or misappropriation in
controlling and managing factors and parameters may have adverse affects in
diabetes management and instead of diabetes level going down will go up
inevitably.
Inefficiency and deregulation in
homeostasis of each and every organ, organs system, muscles tissues and muscle
groups will have relational, exponential or cumulative effects on overall
homeostasis of body which in turn affects diabetes level directly.
So exercising, dieting, maintaining
life style, following self-precautionary measures just aid medication. So, all
controlling measures without medication and medication without them are
worthless.
High cholesterol levels, high lipids
and fats profile, high glycogen storage, high blood pressure levels, imbalances
and weak functioning of organs and organs systems, and muscular atrophy
disrupts relative and overall homeostasis and aids the autonomy as a disease.
High amino acids and ATP profile
will give extra load and effort to muscles tissues and organs and organs systems
which in turn disrupts homeostasis.
Going through strict routines of
exercise, diet and life style management can have negative effects instead so
variations is needed with clear conscience of changing circumstances and
changing need of improvements.
Cholesterol levels rise due to
compromise and measures taken for diabetes management and imbalances and
misappropriation brought about by it is a most significant factor in increasing
blood glucose levels. Increase in cholesterol level is a secondary factor that
causes rise in blood glucose levels.
Maintaining homeostasis in general
for diabetes control and management is not sufficient because relative
variations in homeostasis can spoil overall homeostasis in cognition.
Disrupting of autonomy of diabetes
as a disease is still impossible even we go high or low over exercise, diet,
life style management and self-precautionary measures just we can maintain
overall homeostasis of body by having greater knowledge and understanding of
sciences of anatomy, morphology and philosophy of different muscles tissues,
organs and organ systems and their relative-homeostasis. Also, we should pave
our own way through instinctive measures of whatsoever is good or bad for us.
Diabetes management and control takes time and is possible through progressive
improvements and variations in exercises, proper diet plan, balance in life
style, and having clear conscience over changing circumstances.
Obesity lowers metabolic rate or
lowers hunger of cells for glucose intake. Slowly cells become insulin
tolerant.
Inheritance of genetic disorder or
disease like obesity, medical history from ancestors, prevailing medical
conditions cause plasma membrane dysfunction, plasma membrane dysfunction
brings up cellular dysfunction, cellular dysfunction brings up insulin
dysfunction, and insulin dysfunction brings up pancreatic dysfunction. This
will initiate dysfunction of other organs and organs systems.
Small intestine directly absorbs
glucose and sent back unabsorbed glucose to blood stream. Muscles cells use
oxygen to convert glucose into energy. Unconverted glucose is stored in muscles
tissues, liver and fat tissues as glycogen. Unconverted food into glucose
present in excess amount is stored as visceral fat in epidermis of skin.
Plasma membrane dysfunction
disallows insulin to pass over glucose partially or completely through it to
muscles cell for oxidation. This partial or wholesome glucose goes directly to
blood stream. This slowly makes cells insulin intolerant and develops insulin
resistance. This brings insulin dysfunction. Insulin dysfunction leads to
pancreatic dysfunction. Pancreatic dysfunction leads gradual dysfunction of
other organs and organs systems.
Obese people have low metabolic rate
thus store glycogen, fats cells and visceral fat. They have to eat more because
they have to feed increasing numbers of adipose cells. They are not physically
active so cellular respiration is hampered causing muscles cells not to take
enough glucose to convert into energy for normal functioning of body. They also
live a sedentary life style. They have very high chance of diabetes because
most of glucose is sent to blood stream.
Due to cellular dysfunction, when
muscles cells receive energy directly from glycogen storage, protein cells and
fat cells because metabolic rate of muscles cells has run down and all glucose
goes to blood stream, ketones are released as byproducts which are harmful to
body if present beyond threshold.
When body is in stressful situation
or body is in need of more energy and muscles cells have very less amount of
glucose receipt, muscles tissues receive energy by catabolism of stored
glycogen, protein fibers and stored visceral fats cells. This makes to lose
lean muscle mass, lose stored glycogen and lose stored fats. Thus sudden drop
of body weight is liable. On other hand, more and more storage of glycogen and
visceral fat may lead to obesity.
Cellular expenditure of energy
increases with exercise so cells take more glucose for oxidation. This makes
cells hungry for glucose. Insulin activity increases and insulin resistance
decreases with exercise. A1C decreases which is maintained by increase in
quantity of counter regulatory hormones which maintain blood glucose level
through glycogenesis.
In case, when carbohydrates
metabolism, protein metabolism and fats metabolism is boosted through modular
changes, more glucose is manufactured from food we intake. This will certainly
increase blood glucose levels than normal. This is maintained by increase in
amount of regulatory hormones basically, insulin. Modular changes decrease
insulin resistance and increase insulin activity. This will again drive in more
glucose to muscles tissues for oxidation and blood glucose level is again
maintained.
Glycogen storage decreases, fat is
metabolized and lean muscles mass is added up with change in exercise regimen,
nutrition regimen and life style regimen.
Insulin is a key for shutter opening
of plasma membrane of muscles cells to provide glucose to muscles cells for
their respiration to release energy for normal body function.
Blood stream delivers glucose to
different parts of body. Extra glucose from muscle cells is restored as
glycogen in muscles tissues, liver and adipose tissues.
Metabolic disorder causing diabetes
can disrupt shutter opening mechanism of plasma membrane of cells and cells do
not receive glucose. This glucose directly goes to blood stream causing high
blood glucose levels. Insulin is an aiding hormone for surpassing glucose to
cells through plasma membrane. Slowly cells get habitual of not receiving
glucose at all or not in enough amounts and this bring up insulin resistance.
Insulin resistance after a while causes dysfunction of beta cells to release
insulin. Slowly insulin release is hampered. This brings dysfunction of muscles
tissues, and organs and organs systems dysfunction. Not enough consumption of
glucose by muscles tissues due to insulin inability and resistance brings
obesity due to high visceral fat accumulation. This triggers production of high
levels of glucagon for glycogenesis which again gives extra load to pancreas
and misbalances homeostasis of pancreatic secretions.
In the sense, insulin not only helps
in providing glucose to muscles cells but also helps in glucose consumption.
Liver, fats cells and muscles tissues store extra glucose in the form of
glycogen.
Insulin tends to send extra glucose
to cells to metabolize for glucose homeostasis. Glucagon converts stored
glycogen to glucose and sends directly to blood stream.
Metabolic disorders of body cause
muscles cells less hunger for glucose or energy. This cause muscles tissues
inactivity of conversion of glucose as energy. Since production of glucose is
hampered, muscles tissues glycogen storage is heavily boosted.
Glucagon affects increases when
glycogen storage is boosted. Glucagon and other counter regulatory hormones
activate when blood glucose levels drop beyond threshold.
When body cannot receive enough
energy from cells for proper functioning, the energy compensation runs directly
on protein metabolism and/or fat metabolism rather than carbohydrates
metabolism. Thus, glycogen storage in muscles tissues, liver, adipose tissues
and visceral fat tissues are consumed abruptly causing sudden weight loss and
weakness. This also increases ketones in blood stream which is an indicator of
diabetes.
Modular resuscitation aims at
reversing diabetes affects so that autoimmune affect can be restored and blood
glucose levels may come to normal.
High blood glucose or high A1C is
characterized by depressed metabolism and low metabolic rate of muscles cells.
Diabetes medicines increase insulin
levels. Exercise induces endorphins. Proper diet increases estrogen and
testosterone levels.
Diabetes Homeostasis is a negative
feedback loop in which counter-regulatory hormones especially, glucagon work
antagonistically to regulatory hormones especially, to insulin. Homeostasis is
a balance between insulin and glucagon levels and their activity.
Physiological stress brings up with
a disease increase levels of counter-regulatory hormones. Blood pressure
increases with exercise which in turn can increase blood glucose levels.
Decrease in intake of foods or intermittent dieting may have adverse affect to
diabetes due to homeostasis disruption.
These may be causes for more
glycogen storage and more fat reserve during diabetes leading to obesity:
-
Glucose
cannot reach muscles cells,
-
Glucose
is not metabolized properly by muscles cells, and
-
More
hunger due to increase in adipose tissues and lack of energy of muscles cells
for respiration
·
Obesity
may be caused due to positive feedback loop between insulin and glucagon during
diabetes
This may be a cause for weakness
felt due to depletion of glycogen storage of muscles cells, liver and fats
cells:
-
Glucagon
affect stands more than insulin due to disrupted homeostasis of insulin
secretion. Thus, cut-off of glycogen reserves is triggered due to inactivity
and insufficiency of insulin
Three
factors that affect glucose balance are:
·
Glucose
Index: Increase or decrease in blood sugar level per unit volume of blood,
·
Glucose
Load: Extravagant amount of blood glucose per unit volume of blood, and
·
Insulin
Index: Increase or decrease in insulin level per unit volume of blood
In
diabetics, brain sensing or feedback loop of muscles cells and adipose tissues
to CNS is low causing obesity, nerves imbalance and fatigueness or low energy
level enabling metabolic disorders and genetic diseases in long run.
Factors
causing diabetes with time are:
Ethnicity,
Age,
Obesity,
Genetics,
Medical
History,
Past
Injury, and
Medications
Diabetes is a disorder or condition
in which food is not sufficiently oxidized into glucose or energy by muscles
tissues due to metabolic disorder or homeostasis imbalance caused by insulin
intolerance, high amount of visceral fat triggering glycogenesis rather than
glucogenesis due to imbalance in pancreatic secretions of insulin and glucagon
from beta and alfa cells causing pancreatic hormonal homeostasis imbalance
triggering insulin inactivity. Beta cells get damaged and cannot produce
insulin.
Diabetes
autoimmune is an autoimmune attack due to disruption of glucose metabolism or
glucose homeostasis. It is a degeneration affect which ruins health of any
part(s) or organ(s) of body or overall health of body cumulatively, bringing
physical, mental and emotional complications in short run and bringing
metabolic changes causing genetic disorders in long run. Diabetes autoimmune
can cause organ dysfunction and failure in long run. Thus, it is a measure
cause of death from diabetes.
Autoimmune in diabetes is caused by
malfunction, dysfunction or fault inside the body due to homeostasis imbalance,
pathogenic effects, sedentary life style, over nutrition or under nutrition,
less or weak sleep, physical inactivity, prevailing medical conditions,
disorders, and genetics.
There are three types of
Homeostasis: Normal, Diabetic and Disruptive. Disruptive Homeostasis aids
Diabetic Autonomy.
Homeostasis maintained through
exercise, nutrition, and life style management change attributes is inversely
proportional to A1C levels. A1C level should go down when strict regimens of exercise,
nutrition and life style is undertaken and its liable that A1C level goes up
normally when above regimens are compromised.
Diabetes
Autonomy is a diseased level of glucose metabolism or disrupted glucose
homeostasis causing diabetes.
Diabetes
autonomy means blood glucose levels remain up the threshold margin in each and
every sample(s).
-
Disallows
opening of shutter of plasma membrane,
-
Overloads
insulin activity and enhances glycogen storage,
-
Dysfunction
insulin activity,
-
Cause
insulin resistance,
-
Hamper
insulin secretion,
-
Damage
beta cells,
-
Cellular
respiration is hampered leading muscles dysfunction, and
-
Toxic
wastes or ketones accumulate from muscles cells cause energy is restored from
protein and/or fat metabolism(s) as carbohydrate metabolism is disrupted
Until and unless diabetes
homeostasis is not normalized, diabetes autonomy is maintained. Diabetes
Homeostasis can be normalized through modular resuscitation. Influential
changes and chances of adherences disrupt diabetes autonomy and normalize
glucose metabolism and homeostasis.
During modular resuscitation,
increased blood or decreased glucose levels (A1C) should be maintained by
antagonist affects of regulatory and counter regulatory hormones. When diabetes
autonomy is on run to some level, homeostasis is maintained by insulin and
glucagon. Glucagon will influence more when blood glucose level is low during
influential changes and insulin will influence more when blood glucose level is
high during influential changes (influential changes and adherences maintained
through sustainable exercises, sustainable nutrition and sustainable life
style).
Moderate
weight moderate intensity circuits of compound exercises and compound movements
with aerobic or cardio exercises, flexibility or stretching exercises, strength
or weight training, mobility exercises and mostly resistance training for
decreasing insulin resistance by muscles cells, liver, fat cells and other
parts of the body. Normal rest periods between sets are recommended.
·
Limit sedentary activities such as
television or computer time,
·
Do stretching exercise, or leg lifts
while watching TV,
·
Take the stairs,
·
Get off the elevator one flight away
from your destination and walk up the last flight,
·
Do errands by food or bicycle,
·
Park your car at the far side of the
parking lot,
·
Get off the bus one stop away from
your destination, and walk the rest of the way,
·
Take an after-dinner walk with family
or friends,
·
Spend part of your lunch hour
walking,
·
Walk around the perimeter of the
mall before shopping, and
·
Schedule family time doings
something active
Insulin and Glucagon: Hormonal
Elements Regulation
ANS and CNS: Neural Regulation
Right M & E of exercise
module, nutrition module and life style module lowers effects of counter
regulatory hormones and increases effects of regulatory hormones that help in
normalizing hbAC1 levels.